Penvir 500mg (Famciclovir)
Penvir 500mg is used to cure and suppress herpes labialis (cold sores) and relapsed episodes of genital herpes infection.
Penvir 500mg is required to prevent the symptoms of herpes zoster which is also known as shingles, a herpes virus infection of the skin. Penvir 500mg is used to cure and suppress herpes labialis (cold sores) and relapsed episodes of genital herpes infection.
This medicine is also preventing recurrent herpes virus infections of the mucous membranes (lips and mouth) and genitals in HIV-infected patients.
Even if Penvir 500mg will not cure genital herpes or herpes zoster, it does help relax from the pain and discomfort and helps the sores heal faster. This medicine is available only with your doctor's prescription under the guidance of medical practioners.
Penvir 500mg tablets is a prodrug form of penciclovir which are a nucleoside associated DNA polymerase inhibitor indicated for Immunocompetent Adult Patients Herpes labialis (cold sores): Penvir 500mg indicated for the treatment of recurrent episodes of herpes Labialis. Penvir 500mg used to treatment of recurrent episodes of Genital herpesand used for Suppressive therapy of recurrent episodes. Penvir 500mg is indicated for the treatment of Herpes zoster (shingles) For HIV-Infected Adult Patients, Penvir 500mg is indicated for the treatment of recurrent episodes of orolabial or genital herpes
MECHANISM OF ACTION
Famciclovir readily go through biotransformation to penciclovir, which has preventory activity against HSV types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV). Thymidine kinase then add phosphorus group to penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This blocks HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus prohibiting herpes viral DNA synthesis and multiplication.
Fastly absorbed from the GI tract. The Penvir 500mg has Bioavailability: 77% (penciclovir) and Time to peak plasma concentration 1 hr. Food may delay absorption.
Plasma protein binding of Penvir 500mg is <20%.
changed to penciclovir through deacetylation and oxidation.
Famtrex: excreted through urine (73%); faces (27%). Elimination half-life of Famtrex: 1.6-3 hr.
The recommended dose in Adult for tablet Famtrex
THE PATIENTS SUFFERING WITH HERPES SIMPLEX – SUPPRESSION
The usual dose is 500mg twice a day orally for Immunocompetent patients. The usual dose is 500mg twice a day orally for HIV- Infected patients.
THE PATIENTS SUFFERING WITH HERPES ZOSTER
Dose prescribed is 500mg every 8 hours for 7 days orally.
THE PATIENTS SUFFERING WITH HERPES SIMPLEX LABIALIS
Recurrent herpes labalis: 1500mg single dose orally.
THE PATIENTS SUFFERING WITH HERPES SIMPLEX – MUCOCUTANEOUS / IMMUNOCOMPETENT HOST
The dose is 500mg administrated 3 times a day given orally for 7 to 10 days. The recommended dose for Relapsed episodes is1000mg twice a day for 1 day orally rather 125mg twice a day orally for 5 days.
THE PATIENTS SUFFERING WITH HERPES SIMPLEX – MUCOCUTANEOUS / IMMUNOCOMPROMISED HOST
Relapsed episodes prescribed dose is 500mg twice a day for 7 days.
Microvir was well tolerated, if it occurs provide supportive and symptomatic treatment should be given as appropriately.
LESS COMMON SIDE EFFECTS OF MICROVIR 250MG
- Mood or mental changes
• Hives or welts
• Itching skin
• Bloated, full feeling
• Excess air or gas in the stomach or intestines
• Redness of skin
MORE COMMON SIDE EFFECTS OF MICROVIR 250MG
- High bleeding
INCIDENT NOT KNOWN SIDE EFFECTS OF MICROVIR 250MG
- Black stools
• Bleeding gums
• Blistering, peeling of the skin
• Joint or muscle pain
• Pinpoint red spots on the skin
• Yellow eyes or skin
• Sores, ulcers or white spot in the mouth or on the lips.
Susceptible to famciclovir, penciclovir cream (Denavir), acyclovir (Zovirax), any other medications, or lactose. Consult your doctor Consult your doctor if you had problems with your immune system, (HIV), (AIDS); inherited conditions where the body is not able to tolerate lactose; or kidney or liver disease.
Consult your doctor if you are pregnant, decide to become pregnant, or are breast-feeding. While takingMicrovir treatment If you become pregnant, discuss with doctor about the condition. Penvir 500mg may produce drowsy, dizzy, confused, or disoriented. Avoid drive a car until reaction of medication you feel.
Concomitant use of digoxin with Microvir will slightly increase the digoxin in your blood. Famciclovir combination with probenecid will raise the level of Famciclovir in your blood and increase side effects.
Category B: In animal reproduction studies have not described about the fetal harm but in human studies have no controlled studies carried out in the 1st trimester.
Penvir 500mg Excretion into human milk has no known data. On the safety of penciclovir in nursing infants has no data available. The drug should be avoided in breast feeding mother.
Store the tablet in a closed container Protect away from moisture, heat and direct light Avoid freezing Ask the pharmacist how to dispose the medicine left out.
Immediately administer the medicine as you remember, If you missed any dose.If next dose time reaches swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.
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