Tasigna 150mg (Nilotinib)
Tasigna tablets is mainly indicated in the conditions like; Chronic and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) resistant or intolerant to prior therapy that included Imatinib in adult patients
DESCRIPTION
Nilotinib sold under the brand name Tasigna and its belongs to targeted cancer cells Tasigna is anticancer drugs, which prohibits development of the cancer cells.
Tasigna is a prescription medicine, which sold under the supervision of medical oncologist. Tasigna is also belongs to the class of kinase inhibitors.
INDICATION
Tasigna tablets is mainly indicated in the conditions like; Chronic and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (Ph+ CML) resistant or intolerant to prior therapy that included Imatinib in adult patients
MECHANISM OF ACTION
CML: chronic myelogenous leukemia is caused by BCR-ABL oncogene Tasigna (nilotinib) is a kinase inhibitor, which prohibits BCR-ABL kinase activity. Tasigna link to the ATP-bounding site of BCR-ABL protein Tasigna inhibits proliferation of murine leukemic cell lines and human cell lines derived from patients with Philadelphia positive CML
PHARMACOKINETICS
ABSORPTION
The bioavailability of Tasigna tablets are about 50% The time to high plasma concentration of Tasigna tablet is occurred within 3 hours after administration.
EFFECT OF FOOD
The effect of drug is increased to 82% when the dose was given 30 minutes after a high fat meal when compared to fasted patient.
DISTRIBUTION
The binding of serum protein of the Tasigna is approximately 98% The drug nilotinib blood plasma ratio is 0.68
METABOLISM
Tasigna is metabolized through CYP3A4 mediated oxidation Tasigna is the prime flowing component in the blood stream
ELIMINATION
The Tasigna half life period is approximately 17 hours
DOSAGE MANAGEMENT
DOSAGE MANAGEMENT
The usual dose of Tasigna Tablet should be taken as two times in a day at time intervals of 12 hours. The tablet Tasigna administrated on an empty stomach. Food should not be taken for at least 1 hour after the dose is taken or 2 hours before the dose is taken
Tasigna capsules, should be dispersed in one teaspoon of applesauce for the patients, who are unable to taken through mouth Immediately within 15 minutes this mixture should be taken . concomitant use with hematopoietic growth factors such as erythropoietin or G-CSF is mandatory Also with hydroxyurea or anagrelide
DOSAGE IN ADULT PATIENTS WITH PHILADELPHIA POSITIVE CML-CP
The usual dose of the Tasigna tablet in this condition is 300mg should be given orally as twice daily.
WITH RESISTANT OR INTOLERANT PHILADELPHIA POSITIVE CML-CP AND CML-AP
The recommended dose is 400mg should be administered as orally twice daily
IN PEDIATRICS
The usual dose for child 230mg/m2 should be administred orally twice daily The maximum dose of Tablet Tasigna is 400mg.
PRECAUTIONS
Check blood counts periodically to reduce some complications because Tasigna may cause thrombocytopenia, neutropenia and anemia, While using Tasigna in patient who are suffered these disease Care should be take Hypokalemia Hypomagnesemia Long QT syndrome Pancreatitis and elevated lipase Hepatotoxicity Electrolyte abnormalities Tumor lysis syndrome
SIDE EFFECTS
TASIGNA SIDE EFFECTS
SKIN
Rash, Pruritus, alopecia, dry skin
GIT
Nausea, constipation, diarrhea, vomiting, upper abdominal pain, dyspepsia
NERVE SYSTEM
Headache, dizziness
GENERAL
Fatigue, pyrexia, asthenia, peripheral edema, face edema
MUSCLE
Myalgia, arthralgia, muscle spasm, pain in extremity, back pain
PULMONARY
Cough, oropharyngeal pain, dyspnea
INFECTIONS & INFESTATIONS
Nasopharyngitis, upper respiratory tract infection, influenza, gastroenteritis
EYE
Eyelid edema, periorbital edema
PSYCHIATRIC
Insomnia
VASCULAR
Hypertension
DRUG INTERACTION
While concomitant with strong CYP3A inhibitors leads to rises nilotinib concentrations compared to while using Tasigna alone Tasigna interaction with strong CYP3A inducer leads to decrease nilotinib concentration Interaction of tasgina with proton pump inhibitors: decrease Tasigna efficacy Tasigna concomitant with drugs that may prolong the QT interval like anti-arrhythmic drugs
CONTRAINDICATIONS
Tasigna do not used in the patients who are having; Hypokalemia Hypomagnesemia Long QT syndrome
PREGNANCY & LACTATION
Pregnancy category: D Tasigna tablet avoid during pregnancy condition and women who become pregnant Tasigna not recommended in breastfeeding mothers
STORAGE
Stored at 68°F to 77°F (20°C to 25°C) keep the cartoon away from heat, moisture and light
MISSED DOSE
If patients missed to take the dose of Tasigna should be take within the time, or the missed dose should be skipped and follow the next dosing schedule.
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