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Description

Sofosbuvir is an antiviral medicine used in the treatment of chronic hepatitis C infection. It is also used in patients with liver cancer and hepatitis C infection who are planning to have a liver transplantation. This medicine minimizes the chance of recurrence of the infection after the transplantation. Sofosbuvir is not recommended for use in patients with a known history of hepatitis B infection.

Side effects

Major & minor side effects for Sofosbuvir

  • Chills
  • Ulcers or white spots in the mouth
  • Lower back pain
  • Headache
  • Rash
  • Irritability
  • Diarrhea
  • Nausea
  • Decreased appetite
  • Muscle pain and cramps

Uses of Sofosbuvir

What is it prescribed for?

  • Chronic Hepatitis C
    Sofosbuvir is used in the treatment of chronic hepatitis C virus infection for preventing the growth and spread of the virus in the body.
  • Hepatocellular carcinoma and liver transplantation
    This medicine is used in patients with hepatocellular carcinoma and hepatitis C, who are planning to undergo liver transplantation in order to prevent the recurrence of the infection.
Concerns

Commonly asked questions

  • Onset of action
    The time required for this medicine to show its effect is not clinically established.
  • Duration of effect
    The time until which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

When not to use?

Allergy

This medicine is not recommended for use in patients with a known allergy to sofosbuvir or any other medicines of the same drug class.

Pancreatitis

This medicine is not recommended for use in patients with a known history of Pancreatitis due to the increased risk of worsening of the patient's condition.

Didanosine

When Sofosbuvir is used in combination with ribavirin, it is recommended not to use didanosine since the risk of serious side effects is very high.

Autoimmune hepatitis

The combination of Sofosbuvir, ribavirin, and peginterferon alfa is not recommended for use in patients with a known history of autoimmune hepatitis due to the increased risk of worsening of the patient's condition.

Warnings

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Use with amiodarone

This medicine should be used with extreme caution in combination with amiodarone due to the increased risk of life-threatening cardiac complications including fatal cardiac arrest. This risk is especially higher in the first 48 hours of starting treatment with both these medicines. Coadministration of these medicines should be done only under close medical supervision with provisions to continuously monitor all vital signs of the patient. Replacement with a suitable alternative may be done based on the clinical condition of the patient.

Renal failure

This medicine should be used with caution in patients with a previous history of renal diseases due to the increased risk of renal failure. Close monitoring of kidney function is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be done based on the clinical condition of the patient.

Hepatitis B

This medicine should be used with caution in patients with a known history of hepatitis B due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient. It is advised to test all patients for evidence of current or prior hepatitis B before starting treatment with this medicine.

Dosage

Missed Dose

If a dose of Sofosbuvir is missed, take the dose as soon as you remember it. If it almost time for the next dose, then skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Phenytoin

Rifampicin

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.