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Afanat 40mg

Afanat 40mg (Afatinib )

Afanat 40mg    is used for the first-line treatment for patients with metastatic non-small cell lung cancer(NSCLC)

Feature
Brand name:
Afanat
Active substance:
Afatinib 40mg
Manufacturer:
Natco Pharma Ltd.,
Packaging:
28 Tablets
Product form:
Tablet
Categories
In stock
Active substance: Afatinib
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Description

DESCRIPTION

This is a Phase 2 trial examine the performance of a targeted cancer drug known as Afanat 40mg    .
Afanat 40mg    prohibits the EGFR protein, which is accepting to be included in driving the growth of chordoma tumors.
This study is plan specifically for chordoma patients 18 years or older with recurrent or metastatic tumors.
Afanat 40mg    which is used as prescription drugs under the guidance of oncologist physician.

INDICATION

Afanat 40mg    is used for the first-line treatment for patients with metastatic non-small cell lung cancer(NSCLC)

MECHANISM OF ACTION

Afatinib mechanism by preventing the activity of a group of proteins knowns as epidermal growth factor receptors (EGFR). Epidermal growth factor receptor is a protein which is included in the growth and spread of cancer cells; Afatinib works by inhibiting the action of this protein.

Afatinib should not be taken by people who having EGFR-negative tumors

PHARMACOKINETICS

• Time to peak plasma time is 2-5 hr and bioavailability are 92 %
• Human plasma protein bound is 95%
• The major circulating metabolites are covalent adducts to proteins.
• The drug excretion through feces is 85% and urine 4% • Half-life is 37 hr.

DOSAGE MANAGEMENT

For adult: 40mg taken once per day is the prescribed dose for adult patients with metastatic non-small cell lung cancer Age of 0-17 years prescribed dose is not being studied in children.
Avoid using of Afanat 40mg  drug under 18 years of age
The prescribed dose for renal impairment is given 30mg taken once per day
Administration :
Administer the drug Afanat 40mg  on an empty stomach.
Take the drug Afanat 40mg  1 hour before or 2 hours after a meal
Avoid cutting or crushing the tablet
Overdosage: Overdose is reported in patients whom ingested 360mg of Afanat 40mg  which causes in nausea, vomiting, asthenia, abdominal pain and hence provided supportive measurement for recovery.

PRECAUTION

Serious dehydration can occur with the use of Afanat 40mg  . This may be leads to serious or persistent diarrhea, vomiting, or reduced fluid intake. Dehydration can result in kidney failure, if it is severe enough. While on treatment with this medication, you may be encouraged to drink extra water.
During treatment with Afanat 40mg    will result in hepatotoxicity; monitor with periodic liver testing; withhold or stoptreatment for serious or worsening liver tests
The drug may result in Interstitial lung disease (ILD)
when administrated to pregnant women, Afanat 40mg    will have foetus harm (embryo-fetal toxicity)
Discontinue the drug,  if patients confirm with suspected keratitis or ulcerative keratitis
With Afanat 40mg    have increased sunburn/phototoxicity; may aggravate rash or acne; patients use with caution to limit sun exposure and where sunscreen and protective clothing.
sometimes, Afanat 40mg    has been bind to corneal perforation, a serious injury to the part of the eye which focuses light into the eye. If you have any persistent eye pain or changes in vision, inform your doctor immediately.

SIDE EFFECTS

Common side effects caused :
• Mild diarrhae for 1 day or less
• Decreased appetite
• Nausea and vomiting
• Mouth ulcer
• Acne, itching, dry skin
• Red colour, tenderness, swelling or other signs of infection around your fingernails or toenails
Serious side effects :
• Eye problems – blurred vision, watery eyes, increased sensitivity to light
• Liver problem – stomach pain, feeling tried, dark urine
• Heart problem
• Urine colour changes to dark
• Bleeding or bruising
• Weakness
• Blurred vision
• Rapid heartbeat
• Breathing trouble
• Cough and fever
• Yellowing the skins

DRUG INTERACTION

Co administration of Afanat 40mg    with P-gp inhibitors (cyclosporine A, ketoconazole verapamil) will have high exposure to Afatinib

When interaction of  Afanat 40mg    with P-gp inducers (carbamazepine, phenytoin, phenobarbital) will lowers the exposure to Afatinib

PREGNANCY

Pregnancy category: c
During treatment with Afanat 40mg    Pregnancy should avoid because the drug Afanat 40mg    is administrated to a pregnant woman will harm the foetus.

LACTATION

Afanat 40mg    Excretion into human milk is unknown or will have adverse reaction in a child who is breastfed. Hence decision can take whether to stop breastfeeding or discontinuation of medicine.

STORAGE

  • Afanat 40mg   Store at 25°C
    • Keep Afanat 40mg    away from children
    • Protect away free from moisture and light.

MISSED DOSE

If patient missed to take the dose of Afanat 40mg    , then the missed dose must be skipped and follow the regular dosing schedule. Do not administer double the dose

Consult with doctor and follow the suggestions.

Feature
Brand name
Afanat
Active substance
Afatinib 40mg
Manufacturer
Natco Pharma Ltd.,
Packaging
28 Tablets
Product form
Tablet
Strength
40mg
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