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Alectinib 150mg

Alectinib 150mg (Alectinib)

Alecensa 150mg is prescribed for the therapy in patientsaffected by anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

Feature
Brand name:
Alecensa
Active substance:
Alectinib 150mg
Packaging:
240 Capsules
Product form:
Capsules
Strength:
150mg
In stock
Active substance: Alectinib
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Description

DESCRIPTION

Alecensa 150mg consist of second-generation anaplastic lymphoma kinase (ALK) inhibitor authorized by the US Food and Drug Administration to cure crizotinib-refractory non-small cell lung cancer
Alecensa 150mg inhibits the developments of cancer cells which are then damaged by the body
Alecensa 150mg which is used asprescription drug under the supervision of medical oncologist.

INDICATION

Alecensa 150mg is prescribed for the therapy in patientsaffected by anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

MECHANISM OF ACTION

ALK is a family of proteins known as receptor tyrosine kinases (RTKs), which are included in the growth of cells and the development of new blood vessels which supply them. In patients with ALK-positive NSCLC, an abnormal form of ALK is formedwhichencourage the cancer cells to multiply and grow in an uncontrolled fashion. The active substance in Alectinib, is an ALK inhibitor and acts by stopping the action of ALK, thereby decreasing the growth and spread of the cancer.

ADME

Highplasma concentration 4 hours and bioavailability of Alecensa 37%
Humanplasma proteins binding is 99%
The drug Alecensa has Metabolized by CYP3A4 to its major active metabolite M4, the main circulating moieties in plasma, total radioactivity 76% constituting.
In oral administration, radioactivity 98% was eliminated in feces. dose was excreted in the feces unchanged Alectinib is 84%. Half-life is 33 hours

DOSAGE MANAGEMENT

Non- Small Cell Lung Cancer :
The prescribed dose is 600mg PO BID until disease progression or unacceptable
Renal impairment patient’s prescribed dose is 450mg orally twice in a day
Alecensa is administrated with food.

PRECAUTIONS

When administered to pregnant womenEmbryo-fetal toxicity resulted: Based on data from animal studies and its mechanism of action, Alecensa can cause fetal harm.
While on treatment withAlecensa will causes Symptomatic bradycardia; control heart rate and blood pressure regularly.
Alecensa treatment may causes severemuscle pain and elevated CPK resulted; advise patients to report any unexplained muscle pain, tenderness, or weakness;
During Alecensa treatmentRenal impairment occurred; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events.

SIDE EFFECTS

Alecensa has some side effects while administrating certain condition as follows :
COMMON SIDE EFFECTS :
Muscle pain, Bradycardia, Tiredness, Constipation, Anemia , Hepatotoxicity, Trouble breathing, Shortness of breath , Cough, Fever .
Serious side effects :
Anemia, Fatigue, Liver problems, Hyperglycaemia, Constipation, Hypercalcemia, Muscle and bone pain, Edema, Low potassium.

DRUG INTERACTION

No drug interactions with Alecensa 150mg necessary dosage adjustment have been observed.

CONTRAINDICATION

None

PREGNANCY

Pregnancy Category D: Based on studies of animal and pharmacological action, Alecensa 150mg will cause fetal harm when given to pregnant women
While on treatment with Alecensa, tell the female not to become pregnant

 LACTATION

While on treatment with Alecensa, discuss with the women not to breastfed to infants

STORAGE

Store at below 30°C
Keep the drug in its original container.

MISSED DOSE

If the patient missed to take a dose, then should not to take an extra dose, but before taking the next dose, have the missed dose at the regular time, leave the missed dose. Consult the doctor

Feature
Brand name
Alecensa
Active substance
Alectinib 150mg
Packaging
240 Capsules
Product form
Capsules
Strength
150mg
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