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Gemtaz 200mg

Gemtaz 200mg (Gemcitabine)

Gemtaz 200mg  is a drug which is :

  • Indicated for the treatment of Pancreas cancer
  • Indicated for the treatment with combination of cisplatin for Non-small cell lung cancer
  • Indicated for the treatment with combination of cisplatin for Bladder cancer
  • Indicated for the treatment Soft-tissue sarcoma
  • Indicated for the treatment with combination of paclitaxel for Metastatic breast cancer
  • Indicated for the treatment with combination of carboplatin for Ovarian cancer
Feature
Brand name:
Gemtaz
Active substance:
Gemcitabine 200mg
Manufacturer:
Sun Pharma
Packaging:
1 Vial
Product form:
Injection
In stock
Active substance: Gemcitabine
31 $
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Description

DESCRIPTION

Gemcitabine drug also represented by its brand name, Gemtaz which is a chemotherapy drug doctors classify as an antimetabolite, a group of drugs which reduce the growth of mesothelioma by prohibiting the proliferation of cancer cells and tumor expansion.
Gemtaz 200mg  is a prescription drug which is used under the supervision of medical oncologist

INDICATION

Gemtaz 200mg  is a drug which is :

  • Indicated for the treatment of Pancreas cancer
  • Indicated for the treatment with combination of cisplatin for Non-small cell lung cancer
  • Indicated for the treatment with combination of cisplatin for Bladder cancer
  • Indicated for the treatment Soft-tissue sarcoma
  • Indicated for the treatment with combination of paclitaxel for Metastatic breast cancer
  • Indicated for the treatment with combination of carboplatin for Ovarian cancer

MECHANISM OF ACTION

Tumors form when common cells become cancerous and initiate growing out of control. Normally, a healthy cell will split into a certain number of times, then go through apoptosis, pre-programmed cell death. Cancer cells bypass apoptosis and continue to multiply until they form a tumor.

Gemcitabine blocks the proliferation of rebellious cancer cells by prevent their production of DNA and RNA, the building stops the new cells. Lacking DNA and RNA, a cancer cell can’t regenerate new cells, and undergoes apoptosis.

ADME

By infusion length the volume of distribution is increased Vd: 50 L/m2
Metabolism transformed through nucleoside kinases to two active metabolites such as gemcitabine diphosphate and gemcitabine triphosphate The drug is excreted through urine (92-98%) and Half-life of Gemtaz is 1.7-19.4 hr

DOSAGE MANAGEMENT

Pancreatic cancer:
The usual dose is 1000mg/m2 IV infusion over 30 min once weekly x 7 weeks; rest 1 week
And the dose 1000mg/m2IV once weekly for 3 weeks of each 28-day cycle
Non-small cell lung cancer:
The usual dose is 1000mg/m2IV infusion over 30 minutes on days 1,8 and 15 of each 28-day cycle or The usual dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Administer cisplatin 100mg/m2 IV after gemcitabine on day 1
Breast cancer:
The usual dose is 1250 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle
Dose with paclitaxel 175mg/m2 on day 1 as a 3-hr infusion before gemcitabine
Ovarian cancer:
The usual dose is 1000 mg/m2IV over 30 minutes on days 1 and 8 of each 21-day cycle.
Dose with carboplatin AUC 4 on day 1 after gemcitabine

PRECAUTIONS

  • When treatment a syndrome where fluid from your veins can leak into your tissues and leads a reduction in your blood pressure and fluid to deposited in your tissues and/or lungs
    • By Gemtaz 200mgusage kidney function changes are reported, which can cause kidney failure • By Gemtaz 200mg  usage Liver function changes are reported, which can cause liver failure and may be life-threatening
    • When treatment with Gemtaz 200mg  will leads to Inflammation (swelling) of the lungs and/or thickening of the lung tissues, which may be life-threatening. You may have a dry cough or trouble breathing.
    • Haemolytic uremic syndrome resulted, containing fatalities; permanently stop treatment in patients with HUS or serious kidney impairment; Kidney failure may not be reversible even with stop of therapy.

SIDE EFFECTS

  • Abnormal results in liver function tests.
    • Blood in the urine
    • Sleepiness
    • Mouth ulcers.
    • Diarrhoea or constipation.
    • Cough.
    • Blocked or runny nose.
    • Sweating.
    • Shortness of breath
    • Alopecia
    • Allergic skin rash
    • Cold or flu-like symptoms.
    • Retention of fluid in the body
    • Back pain.
    • Myalgia
    • Loss of appetite.
    • Headache.
    • Insomnia
    • Chills and fever.
    • Weakness

DRUG INTERACTION

No drug interaction studies have been conducted

CONTRAINDICATIONS

Gemtaz 200mg  is contraindicated in patients with known Hypersensitivity

PREGNANCY 

The Gemtaz 200mg  Pregnancy category D
When administrated to a pregnant woman will cause fetal harm to the fetus the pregnant women should be apprised of the possible hazard to a fetus.

LACTATION

Avoid breastfeed during this treatment because the drug Gemtaz 200mg  may excreted into breast milk

STORAGE 

The drug Gemtaz 200mg  Store at 20°C to 25°C (68°F to 77°F)

MISSED DOSE

If failed to take dose, then have the missed dose as soon as possible before next dose time reaches or skip the dose and follow the normal schedule
Consult the doctor

Feature
Brand name
Gemtaz
Active substance
Gemcitabine 200mg
Manufacturer
Sun Pharma
Packaging
1 Vial
Product form
Injection
Strength
200mg
Gemtaz 200mg отзывы
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