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Hertab 250mg

Hertab 250mg (Lapatinib)

Hertab belongs to class of antineoplastic drugs which prevents the development and spreading of cancer cells all over the body. Hertab is indicated for metastatic breast cancer and spreading after using of other chemotherapy drugs.

Feature
Brand name:
Hertab
Active substance:
Lapatinib 250mg
Manufacturer:
Hetero Drugs Ltd.
Packaging:
30 Tablets
Product form:
Tablet
In stock
Active substance: Lapatinib
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Description

DESCRIPTION

Hertab belongs to class of antineoplastic drugs which prevents the development and spreading of cancer cells all over the body. Hertab is indicated for metastatic breast cancer and spreading after using of other chemotherapy drugs.

INDICATION

Hertab with combination of capecitabine is indicated for the treatment of advanced breast cancer after the failure of other cancer medicine.

Hertab is also combined with letrozole is indicated for the treatment postmenopausal women with hormone receptor positive metastatic breast cancer.

MECHANISM OF ACTION

Hertab is a type of classification called kinase inhibitor and act by intracellular tyrosine kinase.

Hertab prohibits ErbB-forced tumor cell growth in vitro and in various animal models. When combination 5-fluracil with Hertab created an additive effect in the 4 tumor cell lines tested. Development inhibits the Hertab tablet effect were examined in trastuzumab-conditioned cell lines.

Hertab provide selective action against breast cancer cell lines selected for long-term growth in trastuzumab-containing intracellularly. Hormone receptor-positive breast cancer cells (with ER [Estrogen Receptor] and/or PgR [Progesterone Receptor]) that co express the HER2 bear to be protection against established endocrine therapies. Synchronously hormone receptor-positive breast cancer cells that initially lack EGFR or HER2 unrecalled these receptor proteins as the tumor becomes resistant to endocrine therapy.

ADME

ABSORPTION

Poor absorbs from the GI tract. peak plasma concentration is approx. 4hrs; bioavailability is 95%. Hertab with food will increase the systemic exposure.

DISTRIBUTION

Plasma protein binding is 99%

METABOLISM

Hertab Metabolized mainly by CYP3A4 and CYP3A5.

EXCRETION

The drug eliminated dose via feces more than 14% and <2% urine.
Eliminated half-life is 24hrs.

DOSAGE MANAGEMENT

The usual dose of Hertab for adult suffering HER2 positive metastatic breast cancer (with Xeloda) is 1250mg once daily for 1-21days continuously repeating.
Femora Combination with Hertab the dose recommended is 1500mg orally once a day continuously once daily every day.
Take the drug Hertab tablet on an empty stomach (1hr before or 1hr after).
OVERDOSE: If overdose occurs, seek to emergency department or call poison control helpline

If you are allergic to lapatinib, then do not use the drug
If you had hepatic problem, cardio disease, an electrolytic imbalance then discusses with doctor whether it’s safe to use or not prior to Hertab treatment.
While patients during pregnancy, it should strictly avoid the drug because it harms the unborn baby or cause birth defects.
There is not known whether Lapatinib passes into breast milk. Hence avoid breast feeding to the infants during Hertab treatment

PRECAUTIONS

If you are allergic to lapatinib, then do not use the drug
If you had hepatic problem, cardio disease, an electrolytic imbalance then discusses with doctor whether it’s safe to use or not prior to Hertab treatment.
While patients during pregnancy, it should strictly avoid the drug because it harms the unborn baby or cause birth defects.
There is not known whether Lapatinib passes into breast milk. Hence avoid breast feeding to the infants during Hertab treatment.

SIDE EFFECTS

Hertab will cause mild to moderate side effects in patients. If symptoms cause serious the inform the doctor as soon as possible.
Common side effect of Hertab 250mg tablets:
Lumbar pain; diarrhae; dry skin; nail of finger toe changes; headache; in digestion problem ; decreased appetite; mild hair loss or thinning; mouth ulcers; nausea; nosebleed; redness and hands and feet will have tingling; weakness; insomnia; vomiting.
Serious side effect of Hertab 250mg tablets:
Severe tightness; difficulty in breathing; unusual bruising or bleeding; unusual itching; yellowing of the eyes or skin; Chest pain; urine will be dark; dizziness or light-headedness; Rapid or irregular heartbeat; pale stools; persistent loss of appetite; severe or persistent cough; severe or persistent diarrhea, nausea, vomiting and skin allergy like itching, rashes, blisters in mouth, face, lip or tongue.

DRUG INTERACTION

Interaction of Hertab tablet with following drugs: Artemether,

Etravirine,Pazopanib,Tracrolimus,Telithromycin,Topotecan,Tramadol,Tretinoin, Voriconazole, Ziprasidone. will increase risk of side effects and drug will not work properly and effect of Hertab may changes.

CONTRAINDICATIONS

Hertab is contraindicated to hypersensitivity condition and any products of recipients of Hertab

PREGNANCY & LACTATION

Hertab 250mg tablet has no adequate and well tolerated details about the drug Hertab 250mg in pregnant women. Excretion into human milk is unknown. Avoid not become pregnant while receiving Hertab treatment.

STORAGE 

Do not use the drug after the medication has expired.
Keep away from the children
. For Discarding the medicine, it should discuss with pharmacist. For proper dispose of chemo drugs.
Store at 20°C – 30°C.

MISSED DOSE

Take the missed dose as you remember soon before the next dose time.
If time to next dose then skip the missed dose and go for daily schedule, don’t make up with extra dose.
Please consult the doctor for further details.

Feature
Brand name
Hertab
Active substance
Lapatinib 250mg
Manufacturer
Hetero Drugs Ltd.
Packaging
30 Tablets
Product form
Tablet
Strength
250mg
Hertab 250mg отзывы
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