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Indivan 400mg

Indivan 400mg (Indinavir)

Indivan with concomitant use of other antiretroviral is indicated for the treatment of HIV infection.

Feature
Brand name:
Indivan
Active substance:
Indinavir 400mg
Manufacturer:
Cipla Ltd
Packaging:
30 Capsules
Product form:
Capsules
Categories
In stock
Active substance: Indinavir
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Description

DESCRIPTION

Indivan capsule is an HIV (human immunodeficiency virus) protease inhibitor. The capsules are formulated as a sulfate salt and available for oral administration. Indivan is an antiviral drug which prevents HIV from proliferation in our body.

It is used to HIV as well as AIDS. Indivan is not a curable medicine for HIV and AIDS. It is a prescription drug recommended under guidance of medical practioners.

INDICATION

Indivan with concomitant use of other antiretroviral is indicated for the treatment of HIV infection. The uses is depends on two clinical trials almost 1 year duration that describes Reduction in the risk of AIDS-defining illnesses or death, A prolonged suppression of HIV RNA

MECHANISM OF ACTION

An enzyme HIV-1 protease is needed for the proteolytic gap of the viral polyprotein precursors fused to the individual functional proteins found in HIV-1 infectious. Indinavir joints to the protease active site and prohibits the activity of the enzyme. This prohibition prevents cleavage of the viral polyproteins causing in the formation of immature non-infectious viral particles.

ADME PROPERTIES

ABSORPTION

Rapidly absorbed, time to high plasma protein is 0.8±0.3 hrs

DISTRIBUTION

human plasma protein bounds of Indivan is 60%

METABOLISM

In hepatic is metabolized

EXCRETION

< 20% of indinavir is eliminatedin the urine unchanged.

HALF LIFE

Half life of Indivan is 1.8 (±0.4) hours.

DOSAGE MANAGEMENT

DOSAGE AND ADMINISTRATION

The usual dosage of Indivan is 800mg administer as two 400mg capsules given orally every 8 hours in combination with other antiretrovirals for the treatment of HIV infections. With Ritonavir then 800mg plus Ritonavir 100mg to 200mg twice a day The patients taking Indivan must be intervals of 8 hours

Indivan should administrated without food with water 1 hour before or 2 hours after meal It can be also taken with other liquids such as skim milk,juice,coffee or tea or with a light meal The patients ensure adequate hydration its prescribed adults drinks at least 1.5 liters of liquids during the course of 24 hours

SIDE EFFECTS
Side effects by Clinical trials experience- adult and adolescents (13 yrs and older) Digestive system: diarrhea, nausea, flatulence, epigastric pain Skin /appendages: rash Hemic/lymphatic system: anemia, leucopenia and thrombocytopenia Metabolic/nutritional: liver function test abnormalities amylase, SGOT, SGPT, hypoglycemia, dehydration Musculoskeletal system: arthralgia, arthritis, cramps,myalgia Respiratory: dyspnae, pharyngitis, rhinitis, and sinusitis. Special sense: acute iritis and eye disorder.

POSTMARKETING EXPEIENCE
Hypersensitivity reaction Qtc prolongation Jaundice Bilirubinemia, metabolic acidosis.

PRECAUTION

NEPHROLITHIASIS/ UROLITHIASIS

Nephrolithiasis events cumulative frequency increase with increasing exposure of Indivan hence risk over time remains the same

HEMOLYTIC ANEMIA

Acute hemolytic anemia involves cases reports in death. Hence discontinuation of Indivan

HEPATITIS

The patient having hepatitis has been treated with Indivan will leads to hepatic failure and death

FAT REDISTRIBUTION

The mechanism and long term consequence of these events are currently unknown. A causal relationship has not been established.

DRUG INTERACTION

Combination of indinavir with drugs metabolized by CYP3A4 wills increases plasma concentration of the other drugs. Interaction with drugs that induce CYP3A4 activity will increase clearance of indinavir, resulting in reduced plasma concentrations of indinavir

CONTRAINDICATION
Indivan contraindicated in Hypersensitivity to any of its components Inhibition of CYP3A4

PREGNANCY 

There have no adequate and well developed studies in pregnant women. It should be used when potential benefit clarify the possible risk of the fetus

LACTATION

It is not known whether excreted in human milk, breast feeding mothers to be advice to discontinue if they receive Indivan.

STORAGE

Stored in tightly closed container and temperature at 15-30°C Dispense in original container.

MISSED DOSE

If patients missed a dose then have the drug while you remember before next dose timing. Or skip the missed dose and follow regular schedule Please consult with the doctor.

Feature
Brand name
Indivan
Active substance
Indinavir 400mg
Manufacturer
Cipla Ltd
Packaging
30 Capsules
Product form
Capsules
Strength
400mg
Indivan 400mg отзывы
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