0
Products in the cart
Total:
Information block example
Currency
English Support
Request a call
Working hours:
Пн-Пт 9:00—23:00;
Сб-Вс 10:00-20:00

Myezom 2mg

Myezom 2mg (Bortezomib)

Myezom 2mg  is indicated to treat the patients suffering from multiple myeloma. Mantle cell lymphoma Myezom 2mg  is indicated to treat the disease mantle cell lymphoma which the patients have received at least 1 prior therapy.

Feature
Brand name:
Myezom
Active substance:
Bortezomib 2mg
Manufacturer:
Dr.Reddys
Packaging:
1 Vial
Product form:
Injection
In stock
Active substance: Bortezomib
0 $
Available options:
Amount:
To wishlist
Compared
Consulting:+91(994)0472902
Description

DESCRIPTION

Bortezomib is sold under the brand name Myezom 2mg  which is a type of anti-cancer medicine, which is in the form of lyophilized powder A first beneficial proteasome inhibitor is known as Myezom 2mg  ; proteasome is a cellular structure which breaks the proteins.

Myezom 2mg  injection will helps to prevent from multiple myeloma in patients with or without before treatment history and mantle cell lymphoma.

INDICATION

Multiple myeloma Myezom 2mg  is indicated to treat the patients suffering from multiple myeloma. Mantle cell lymphoma Myezom 2mg  is indicated to treat the disease mantle cell lymphoma which the patients have received at least 1 prior therapy.

MECHANISM OF ACTION

Myezom 2mg  injection used in mammalian cells is a reversible inhibitor of the chymotrypsin-like activity of the 26-S proteasome. The drug prohibits targeted proteolysis that affects multiple signaling cascades responsible for normal homeostatic functions within the cell, leading to cell death.

ADME

ABSORPTION

The peak plasma concentration after 1st dose is 57 and 112ng/mL, If administrated two times a week, Cmax observed for 1mg/m2dose is 67 to 106ng/mL, for 1.3mg/m2 is 89 to 720ng/mL.

DISTRIBUTION

human serum plasma concentration is >80%

METABOLISM

Myezom 2mg  injection metabolized mainly through cytochrome P450 isoenzymes CYP3A4, CYP2C19 & CYP1A2.

ELIMINATION

The excretion pathways of Myezom 2mg  have not been characterized. The terminal elimination of half life after the 1mg/m2 dose is 40hrs - 193hrs, after dose 1.3mg/m2 is 76hrs - 108hrs.

DOSAGE MANAGEMENT

MYEZOM 2MG  DOSAGE AND ADMINISTRATION

Myezom is administrated alone or combination with dexamethasone Three week course is considered as therapy cycle Atleast 72 hours must slip away between constant doses of Myezom . Myezom (lyophilized powder form) is reconstituted by using 0.9% sodium chloride (NS) Myezom should be reconstituted in 3.5ml NS The route of administration is IV bolus Intrathecal not use for administration In adults:

MANTLE CELL LYMPHOMA

The Myezom recommended dose for untreated mantle cell lymphoma is;1.3mg/m2 of Myezom administered as IV bolus given as two times weekly by combining with rituximab, cyclophospahmide, doxorubicin and tablet prednisolone for two weeks (day I, IV, VIII & XI) followed rest period of 10 days (day II through 21). In Relapse stage: The normal dose of Myezom is 1.3mg/m2 administered as IV bolus or subcutaneous two times for two weeks (day I, IV, VIII & XI) followed by 10 day rest period (day II through 21) The therapy should followed for above 8 cycles may be given for once weekly for 4 weeks (day 1, 8, 15 & 22), followed by 13 day rest (days 23 through 35)

MULTIPLE MYELOMA

In the therapy of previously untreated multiple myeloma:1.3mg/m2 of dose must be given as 3 to 5 seconds through IV bolus or subcutaneous by concomitant use with tablet melphalan and prednisolone for nine 6 weeks therapy cycles Cycles 1 over 4, Myezom is administrated for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) Cycles 5 over 9, Myezom is administrated once a week (day 1, 8, 22, and 29)

KEY POINTS

Moderately, 72 hours should be passing between following doses of Myezom 2mg

IN RELAPSE STAGE

The usual dose of Myezom is 1.3mg/m2 should be administered through IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) continued by a ten day of rest course (day 12 through 21) The schedule of the treatment has been raised above 8 cycles may be taken once weekly for 4 weeks ( day 1, 8, 15, and 22), followed by 13 day rest (day 23 over 35)

PRECAUTIONS

While taking Myezom 2mg  some adverse effects occurs care should be taken in the conditions like Myezom 2mg  leads to peripheral neuropathy like burning sensation, hyperesthesia, hypoesthesia, paresthesia, neuropathic pain Manage postural Hypotension by altering the antihypertensive agents, hydration, and administration of mineralocorticoids or sympathomimetics Cardiac toxicity Pulmonary toxicity like Acute Respiratory Distress Syndrome, pneumonitis, interstitial pneumonia, lung infiltration Posterior reversible encephalopathy syndrome-stop the Myezom 2mg  therapy Gastrointestinal toxicity-fluid or electrolyte replacements have to take Thrombocytopenia and neutropenia Tumor lysis syndrome Hepatic toxicity Embryo fetal toxicity

SIDE EFFECTS

MOST COMMON SIDE EFFECTS

Black tarry stools ; Bleeding gums ; Blood in urine ; Blurred vision ; Body aches ; Burning, crawling, itching, numbness, prickling ;Chest pain ; Cough producing mucus, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, ear congestion, loss of voice

LESS COMMON SIDE EFFECTS

loss of appetite, Muscle cramps Belching, bone pain, difficulty with moving & bowel movements, cold and shivering, loss of taste, , muscle pain, stomach discomfort. Vomiting, loss of weight ; irregular breathing , Swelling of peripheral organs , Dilated veins, discomfort, increased sensitivity of pain & touch, , heart beats, , thickening of bronchial secretions

DRUG INTERACTION

Interaction with Strong CYP3A4 inhibitors then there is a chance of getting Myezom 2mg  toxicity; so to reduce the dose of Myezom 2mg  while concomitant with CYP3A4 inhibitors Strong CYP3A4 inducers: decrease the exposure of Myezom 2mg  Do not use combination with st. Johns wort to lowers the exposure of Myezom 2mg  While concomitant with melphalan-prednisone or dexamethasone alone has no clinical effect on Myezom 2mg  exposure

PREGNANCY

Myezom 2mg  is not recommended in pregnancy condition, it causes harm to fetus Breast feeding is not recommended.

LACTATION

The drug excreted into human milk is unknown and effects in the new born baby are unknown

Hence use is contraindicated

STORAGE 

Myezom 2mg  vial should be stored at 20°C to 25°C (68°F to 77°F) excursion between 15°C to 30°C (59°F to 86°F). Keep away from light and heat.

MISSED DOSE

If a single dose missed then administer the dose as you remember, If it is near to next dose then skip the missed dose and follow the regular schedule. Do not take extra dose at a time. Consult with the doctor for further changes in dose.

Feature
Brand name
Myezom
Active substance
Bortezomib 2mg
Manufacturer
Dr.Reddys
Packaging
1 Vial
Product form
Injection
Strength
2mg
Myezom 2mg отзывы
Add a comment
0

We use cookies to make the site better for you! Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educati
Lorem Ipsum adalah text contoh digunakan didalam industri pencetakan dan typesetting. Lorem Ipsum telah menjadi text contoh semenjak tahun ke 1500an, apabila pencetak yang kurang terkenal mengambil sebuah galeri cetak dan merobakanya menjadi satu buku spe