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Myhep All

Myhep All (Sofosbuvir & Velpatasvir)
Brand:
Mylan

Myhep All is related with the treatment of unending hepatitis C viral infection.

Feature
Brand name:
Myhep All
Active substance:
Sofosbuvir 400mg, Velpatasvir 100mg
Manufacturer:
Mylan
Packaging:
28 Tablets
Product form:
Tablet
In stock
Active substance: Sofosbuvir & Velpatasvir
165 $
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Description

DESCRIPTION

Sofosbuvir is related with the treatment of unending hepatitis C viral infection. Sofosbuvir isn't used as Monotherapy; it is used by joining with Velpatasvir Both the dynamic fragments are demonstrating movement against hepatitis contamination.

Sofosbuvir and Velpatasvir are doctor prescribed medications; it is used by the patient simply under the guaindance of restorative counsel (hepatologist).

Myhep All is a doctor prescribed pharmaceutical; it is taken by the patients simply under the course of medicinal expert Myhep All is a settled dosage blend calm, contains Sofosbuvir and Velpatasvir as a working fixings. Both the fragments show against viral activity. Myhep All tablet is dynamic against contamination which causes hepatitis C illness in adults Myhep All comprises of; Sofosbuvir-HCV NS5B polymerase inhibitor Velpatasvir-HCV NS5A inhibitor

MYHEP ALL TABLETS WORKS

Sofosbuvir is a NS5B protein inhibitor; protein is essential for viral age. Sofosbuvir is a prodrug shape, which get changed over into dynamic uridine triphosphate outline which is required for against viral development. This dynamic moiety is getting implanted into HCV RNA with the help of NS5B polymerase and leads as chain eliminator. Velpatasvir is pharmacologically goes about as NS5A inhibitor; this protein is required for HCV viral age. Velpatasvir is incorporated its action in viral age process. The major mechanism of Myhep All is involved in prohibition of viral production by intercedes the NS5A & NS5B proteins.

PHARMACOKINETIC

Maximum plasma concentration time: Sofosbuvir 0.5 to 1 hour & Velpatasvir 3 hours. Myhep All should be given with food or without food. Human protein binding nature of Myhep All : Sofosbuvir 61 to 65% & Velpatasvir >99.5% & the circulating metabolite of Sofosbuvir is GS-331007 has low binding effect.

Myhep All metabolism occurs in liver, with the help of cathepsin A, carboxyl esterase 1for sofosbuvir; CYP2B6, CYP2C8 or CYP3A4 for Velpatasvir. Excretion of Myhep All should be occurs through glomerular filteration & active tubular secretion & biliary excretion.

Sofosbuvir doses are eliminated via urine as 80%, feces as 14% & exhaled air as 2.5%. Velpatasvir doses are eliminated via urine as 0.4% & feces as 94%.

The half life period of Myhep All is; Sofosbuvir 0.4 hour GS-331007: 27 hours Velpatasvir: 15 hours

DOSAGE MANAGEMENT

BEFORE START THE THERAPY

Explore the patients altogether, before beginning the treatment with HCV hostile to viral specialists. Alert ought to be taken while utilizing HCV medicines in patients with HCV/HIV-1co contaminations, for this situation HBV revival happens. Myhep All tablets are suggested for perpetual state of hepatitis C viral contamination caused by genotype 1, 2, 3, 4, 5 or 6. The dosing regimens of Myhep All ; The typical endorsed dosage of Myhep All is, one tablet ought to be taken orally as an once every day. Myhep All tablet contains 100mg of Velpatasvir and 400mg of Sofosbuvir

OVER DOSAGE

At the time of over dose, patients must be furnished with general consistent treatment. Over dosage should be managed by hemodialysis. Velpatasvir is hard to remove by dialysis process since it is uncommonly connections to human plasma protein. Sofosbuvir revolving around metabolites get abstained from through dialysis with extent of 53%.

THERAPY DURATION
PATIENTS WITH COMPENSATED CIRRHOSIS OR WITHOUT CIRRHOSIS

One tablet of Myhep All should be administered orally as once daily over period of 12 weeks.

PATIENTS WITH DECOMPENSATED CIRRHOSIS

One Myhep All tablet should be combined with weight based ribavirin by administering with food for 12 hours.

THE DOSE OF RIBAVIRIN SHOULD BE CALCULATED FOR THE PATIENTS

Patient with <75kg of body weight, the recommended dose of ribavirin is 1000mg administered as twice daily. Patient with at least 75kg of body weight, recommended dose of ribavirin is 1200mg administered as twice daily. For both renal & hepatic impaired patients; Myhep All tablets dosage adjustment should not be recommended.

SIDE EFFECTS

UNFAVORABLE EFFECTS

Serious bradycardia occurs due to concomitant use of Myhep All with amiodarone. Insomnia Irritability Headache Fatigue Nausea Asthenia

LAB ABNORMALITIES

Lipase elevation Elevation of creatine kinase Elevation of bilirubin levels

POST MARKETING EFFECTS

Cardiac disorders Rashes Angioedema

SAFETY MEASURES

BRADYCARDIA

This opposing occurs by mix of Myhep All with amiodarone; causes extended joining of amiodarone prompts outrageous bradycardia. To overcome the issue by; Stop the combinational treatment ECG checking Start supportive medication for decreasing the cardiovascular issues

LOSS OF IMPACT BECAUSE OF BLEND OF MYHEP ALL WITH P-GP INDUCERS

The synchronous use of Myhep All with P-gp inducers causes loss of therapeutic activity of Myhep All .

UTILIZATION OF RIBAVIRIN WITH VELASOF

Fetal mischief condition is a result of the orderly usage of Myhep All with ribavirin in the midst of pregnancy period.

DRUG INTERACTION

The combination of Myhep All with P-gp inducers potent produces lack of anti-viral activity due to diminished concentration of sofosbuvir. The co administration of Myhep All with P-gp or BCRP inhibitors causes exposure of adverse effects associated with these substrates. The concurrent of Myhep All with warfarin causes fluctuation in prothrombin time or INR values.

The co administration of Myhep All with acid reducing agents should be avoided; this may causes loss of activity by reducing the concentration of ingredients in Myhep All The combination of Myhep All with amiodarone should be abstained. This combination causes bradycardia.

The concurrent use of Myhep All with anti-convulsants or anti-mycobacterials causes diminishing the concentration of Velpatasvir or sofosbuvir. The concomitant use of Myhep All with st Johns wort causes loss of activity of Myhep All due to decreased concentration of ingredients of Myhep All The combination of Myhep All with HMG CoA reductase inhibitors causes increasing the concentration of these drugs.

CONTRAINDICATION

Myhep All is contraindicated to pregnancy & lactating women, while it is combined with ribavirin. Some hypersensitivity reactions are produced due to patients are contraindicated to the components of Myhep All .

PREGNANCY & LACTATION

Myhep All pregnancy category B Myhep All with ribavirin pregnancy category X Ribavirin is contraindicated to pregnancy period. Breast feeding should not be allowed.

PEDIATRIC & GERIATRIC

The potency of Myhep All has not been established in pediatric patients. No dosage adjustment should be recommended.

STORAGE 

Myhep All storage temperature is below 30°C. Keep away from moisture, heat & light.

MISSED DOSE

In case of missed dose, patient should get advice from medical practitioner and follow the regular dosing schedule. On the other hand the missed dose is skipped.

Feature
Brand name
Myhep All
Active substance
Sofosbuvir 400mg, Velpatasvir 100mg
Manufacturer
Mylan
Packaging
28 Tablets
Product form
Tablet
Myhep All отзывы
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