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Penvir 250mg

Penvir 250mg (Famciclovir)

Penvir 250mg is required to prevent the symptoms of herpes zoster which is also known as shingles, a herpes virus infection of the skin. Penvir 250mg is used to cure and suppress herpes labialis (cold sores) and relapsed episodes of genital herpes infection.

Feature
Brand name:
Penvir
Active substance:
Famciclovir 250mg
Manufacturer:
Hetero Drugs Ltd.
Packaging:
6 Tablets
Product form:
Tablet
In stock
Active substance: Famciclovir
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Description

DESCRIPTION

Penvir 250mg is required to prevent the symptoms of herpes zoster which is also known as shingles, a herpes virus infection of the skin. Penvir 250mg is used to cure and suppress herpes labialis (cold sores) and relapsed episodes of genital herpes infection.

This medicine is also preventing recurrent herpes virus infections of the mucous membranes (lips and mouth) and genitals in HIV-infected patients.

Even if Penvir 250mg will not cure genital herpes or herpes zoster, it does help relax from the pain and discomfort and helps the sores heal faster. This medicine is available only with your doctor's prescription under the guidance of medical practioners.

INDICATION

Penvir 250mg tablets is a prodrug form of penciclovir which are a nucleoside associated DNA polymerase inhibitor indicated for Immunocompetent Adult Patients Herpes labialis (cold sores): Penvir 250mg indicated for the treatment of recurrent episodes of herpes Labialis. Penvir 250mg used to treatment of recurrent episodes of Genital herpesand used for Suppressive therapy of recurrent episodes. Penvir 250mg is indicated for the treatment of Herpes zoster (shingles) For HIV-Infected Adult Patients, Penvir 250mg is indicated for the treatment of recurrent episodes of orolabial or genital herpes

MECHANISM OF ACTION

Famciclovir readily go through biotransformation to penciclovir, which has preventory activity against HSV types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV). Thymidine kinase then add phosphorus group to penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This blocks HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus prohibiting herpes viral DNA synthesis and multiplication.

ADME PROPERTIES

ABSORPTION

Fastly absorbed from the GI tract. The Penvir 250mg has Bioavailability: 77% (penciclovir) and Time to peak plasma concentration 1 hr. Food may delay absorption.

DISTRIBUTION

Plasma protein binding of Penvir 250mg is <20%.

METABOLISM

changed to penciclovir through deacetylation and oxidation.

ELIMINATION

Famtrex: excreted through urine (73%); faces (27%). Elimination half-life of Famtrex: 1.6-3 hr.

DOSAGE MANAGEMENT

The recommended dose in Adult for tablet Famtrex

THE PATIENTS SUFFERING WITH HERPES SIMPLEX – SUPPRESSION

The usual dose is 250mg twice a day orally for Immunocompetent patients. The usual dose is 250mg twice a day orally for HIV- Infected patients.

THE PATIENTS SUFFERING WITH HERPES ZOSTER

Dose prescribed is 250mg every 8 hours for 7 days orally.

THE PATIENTS SUFFERING WITH HERPES SIMPLEX LABIALIS

Recurrent herpes labalis: 1250mg single dose orally.

THE PATIENTS SUFFERING WITH HERPES SIMPLEX – MUCOCUTANEOUS / IMMUNOCOMPETENT HOST

The dose is 250mg administrated 3 times a day given orally for 7 to 10 days. The recommended dose for Relapsed episodes is1000mg twice a day for 1 day orally rather 125mg twice a day orally for 5 days.

THE PATIENTS SUFFERING WITH HERPES SIMPLEX – MUCOCUTANEOUS / IMMUNOCOMPROMISED HOST

Relapsed episodes prescribed dose is 250mg twice a day for 7 days.

OVERDOSAGE

Microvir was well tolerated, if it occurs provide supportive and symptomatic treatment should be given as appropriately.

SIDE EFFECTS
LESS COMMON SIDE EFFECTS OF MICROVIR 250MG

  • Mood or mental changes
    • Hives or welts
    • Itching skin
    • Bloated, full feeling
    • Excess air or gas in the stomach or intestines
    • Redness of skin

MORE COMMON SIDE EFFECTS OF MICROVIR 250MG

  • High bleeding
    • Headache
    • Diarrhea
    • Cramps

INCIDENT NOT KNOWN SIDE EFFECTS OF MICROVIR 250MG

  • Black stools
    • Bleeding gums
    • Blistering, peeling of the skin
    • Dizziness
    • Joint or muscle pain
    • Pinpoint red spots on the skin
    • Yellow eyes or skin
    • Sores, ulcers or white spot in the mouth or on the lips.

PRECAUTION

Susceptible to famciclovir, penciclovir cream (Denavir), acyclovir (Zovirax), any other medications, or lactose. Consult your doctor Consult your doctor if you had problems with your immune system, (HIV), (AIDS); inherited conditions where the body is not able to tolerate lactose; or kidney or liver disease.

Consult your doctor if you are pregnant, decide to become pregnant, or are breast-feeding. While takingMicrovir treatment If you become pregnant, discuss with doctor about the condition. Penvir 250mg may produce drowsy, dizzy, confused, or disoriented. Avoid drive a car until reaction of medication you feel.

DRUG INTERACTION

Concomitant use of digoxin with Microvir will slightly increase the digoxin in your blood. Famciclovir combination with probenecid will raise the level of Famciclovir in your blood and increase side effects.

PREGNANCY

Category B: In animal reproduction studies have not described about the fetal harm but in human studies have no controlled studies carried out in the 1st trimester.

LACTATION

Penvir 250mg Excretion into human milk has no known data. On the safety of penciclovir in nursing infants has no data available. The drug should be avoided in breast feeding mother.

STORAGE

Store the tablet in a closed container Protect away from moisture, heat and direct light Avoid freezing Ask the pharmacist how to dispose the medicine left out.

MISSED DOSE

Immediately administer the medicine as you remember, If you missed any dose.If next dose time reaches swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.

Feature
Brand name
Penvir
Active substance
Famciclovir 250mg
Manufacturer
Hetero Drugs Ltd.
Packaging
6 Tablets
Product form
Tablet
Strength
250mg
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