Posid 100mg (Etoposide)

DESCRIPTION

Posid 100mg consist of semisynthetic derivative of the mandrake plant substance podophyllotoxin, persuaded DNA strand breaks by preventing the activity of topoisomerase II and generating free radicals.
Posid 100mg Injection is taken by mouth or Injection into a vein.
Posid 100mg Injection which used as prescription drug provided under guidance of medical practioners.

INDICATION

Posid 100mg Injection used in concomitant use with other cancer medication in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer.

MECHANISM OF ACTION

Etoposide has been revealed to cause metaphase capture in chick fibroblasts. Its major effect, however, occurs to be at the G2 portion of the cell cycle in mammalian cells. Two variety dose-dependent reaction are observed. At high concentrations (10 mcg/mL or more), lysis of cells penetrate mitosis is observed. At low concentrations (0.3 to 10 mcg/mL), cells are prohibiting from entering prophase. It does not prevent microtubular assembly. The potent macromolecular effect of Etoposide results to be the DNA strand induction breaks by a combination with DNA topoisomerase II or the production of free radicals.

ADME

• High plasma time is 1 hr
  • Bioavailability are 25-75%
  • Plasma Protein bound has 94-98% and Vd: 7-17 L/m²
  • The drug Metabolized in Liver
  • The drug Excretion through Urine (35%)
  • Half-Life: 4-11 hr

DOSAGE MANAGEMENT

The usual dose for testicular cancer of Posid Injection is 50-100mg/m2/day Iv on days 1-5 or 100mg/ m2/day IV on days 1,3,5 and Repeat the course for q3-4week.
The usual dose for small-cell lung cancer of Posid Injection is 35 mg/ m2/day IV for 4 days or 50 mg/ m2/day IV for 5 days. And Repeat the course for q3-4week.
Regulate for the patients CBC, Hgb, LFTs, Renal function.

PRECAUTIONS

While using Posid 100mg will have serious myelosuppression, which could in bleeding and infection, may resulted
If platelet <50,000/mm³ or ANC <500/mm³, withhold further treatment
Patients with decreased serum albumin may be at increased for Posid 100mg along with toxicities
The drug Posid 50mgshould not inject fastly it may cause low blood pressure to patient; infuse over at least 30-60 min
While using Posid 100mg Injection site reactions may occur; check closely.
While treatment with Posid 100mg may cause infertility in females of reproductive probably and result in amenorrhea; premature menopause can occur.

SIDE EFFECTS

Initial stage side effects of Posid 100mg Injection :
Loss of appetite
Nausea and vomiting
Allergic reaction like coughing, stuffy nose, sneezing, itching, flushed skin or rash Dyspnea, low or high blood pressure and chest pain Later stages side effects of Posid 100mg Injection :
Hypotension
Reduce WBC count
Decreased platelet count
Loss of hair
Menopause
Fertility loss
Mouth ulcers
Diarrhae
Radiation Recall
Changes in liver function temporarily

DRUG INTERACTION

The drug Posid 100mg will reduces the influenza virus vaccine trivalent effects adjuvanted by pharmacodynamic antagonism Combination of Posid 100mg with idelalisib may increase level or effect of Etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Combination of Posid 100mg with Apalutamide will reduces the level or effect of Etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Combination of Posid 100mg with Nefazodone will increase the level or effect of Etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

CONTRAINDICATIONS

The drug Posid 100mg contraindicated to hypersensitivity to Etoposide or any component of the formulation.

PREGNANCY 

Posid 100mg has pregnancy category D
While administrating to a pregnant woman will cause fetal harm. Hence the drug during pregnancy

LACTATION

Avoid breastfeeding during treatment because of possible risk to the fetus

STORAGE 

Posid 100mg should be stored under refrigeration at 2°C-8°C.
Dispense the drug in tight container.

MISSED DOSE

If the patient missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose.