0
Products in the cart
Total:
Information block example
Currency
English Support
Request a call
Working hours:
Пн-Пт 9:00—23:00;
Сб-Вс 10:00-20:00

Psorid 100mg

Psorid 100mg (Cyclosporine)

Psorid 100mg used for the prohibits rejection of a transplanted organ.

Feature
Brand name:
Psorid
Active substance:
Cyclosporine 100mg
Manufacturer:
Biocon Ltd
Packaging:
50 Capsules
Product form:
Capsules
In stock
Active substance: Cyclosporine
0 $
Available options:
Amount:
To wishlist
Compared
Consulting:+91(994)0472902
Description

DESCRIPTION

Cyclosporine is sold under the brand name Psorid .
Psorid   belongs to immunosuppressant drug which has been needed since the early 1980s to inhibits organ
rejection after transplantation such as a liver transplant.
Psorid   which used as prescription drug under the guidance of medical practioners.

INDICATION

Used for the prohibits rejection of a transplanted organ.

Used to reduce inflammation in active rheumatoid arthritis and severe psoriasis.

MECHANISM OF ACTION

Cyclosporine consist of natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria Nivea.

The proper mechanism of action of Cyclosporine isunknown but may contains binding to the cellular protein cytophilic, reports in prevention of the enzyme calcineurin. This agent occurs to especially and reversibly prohibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially prohibited with T-helper cells as the primary target. Cyclosporine also prevents lymphokine production and release.

ADME PROPERTIES

Incomplete and variable absorption from GI tract and bioavailability is 30%
The time to peak plasma concentration is 1.5-2.0 hours
Human plasma protein bound is 90%
In liver largely metabolized by the cytochrome P450 3A enzyme system. To minor degree is metabolized in gastrointestinal tract and kidney.
Primarily excreted in biliary and in urine 6% and 0.1% eliminated in urine as unchanged drug.
Half-life in adults is 19 hours and in children is 7 hours

DOSAGE AND ADMINISTRATION

Solid Organ Transplantation :
Safety measures of organ rejection in kidney, liver,andheart allogeneic transplants; has been required in concomitant usewith azathioprine and corticosteroids.
In Oral route :
For 4-12 hours pre-transplant recommended dose is 15 mg/kg orally for 1 dose required
For 1-2 weeks post-transplant recommended dose is 15 mg/kg/day orally divided twice daily required.
For reduce 5% per week until can tolerate recommended dose is 5-10 mg/kg/day orally divided twice daily required
In Intravenous (IV) route :
For 4-12 hours pre-transplant IV recommended dose is 5-6 mg/kg IV for 1 dose over 2-6 hours required.
For Post-transplant, until can tolerate oral therapy recommended dose is 5-6 mg/kg IV once/day required.
Solid Organ Transplantation, Paediatric (Off-Label)
In 6 months, young children have gettingPsorid to prevents solid organ transplant rejection.
Dosage is same as adults, even if children may need higher mg/kg dose than adults
In Oral route :
For 4-12 hours pre-transplant recommended dose is 15 mg/kg orally for 1 dose required
For 1-2 weeks post-transplantrecommended dose is 15 mg/kg/day orally divided twice daily required.
For reduce 5% per week until recommended dose is 5-10 mg/kg/day orally divided twice daily required.
In Intravenous (IV) route :
For 4-12 hours pre-transplant IV recommended dose is 5-6 mg/kg IV for 1 dose over 2-6 hours required
For Post-transplant, until can tolerate oral therapy recommended dose is 5-6 mg/kg IV once/day required
Rheumatoid Arthritis :
Prescribed for severe active, rheumatoid arthritis where the disease has not adequate responded to methotrexate; may be required in concomitant use with methotrexate.
Psorid 1.25 mg/kg orally twice daily; may increase by 0.5-0.75 mg/kg/day after 8 weeks and again after 12 weeks if needed, not to exceed 4 mg/kg/day
Stop if no improvement observed by 16 weeks
Decrease the dose by 25-50% at any time to regulate adverse effects (e.g., hypertension, elevations in serum creatine greater than 30% pre-treatment level
Psoriasis :
The recommended dose of Psorid is 1.25 mg/kg orally twice daily; may raise by 0.5 mg/kg/day after 4 weeks and every 2 weeks if needed, not to exceed 4 mg/kg/day
Stop if no improvement seen at 6 weeks on maximum daily dose of 4 mg/kg/day
Decrease the dose by 25-50% at any time to regulateside effects (e.g., high blood pressure, elevations in serum creatine greater than 30% pre-treatment level

SIDE EFFECTS

Serious side effects :
Liver damage - blood in urine; dark urine; pale stools; yellowing of your skin or the whites of your eyes; pain in your upper abdomen
Kidney damage. Symptoms may include: blood in urine
Heart problems. Includes swelling of your feet or lower legs
Lung problems. Symptoms may include: trouble breathing.
More common side effects :
Hypertension
Magnesium level is low in body
In kidneys, blood clots occur
Stomach pain
Hair growth
Acne
Tremors
Headache
Gums size increased.

PRECAUTION

While on treatment with Psorid   may have high risk of serious infections. It may also raise the risk of developing a tumor or skin cancer.
While on treatment with Psorid   weakens the immune system. If you administer this medication, you may be at higher risk for infections from bacteria, fungus, and viruses. These infections may be serious or life-threatening If patient have psoriasis and have been treated with either psoralen plus ultraviolet A therapy, methotrexate, coal tar, radiation therapy, or ultraviolet light therapy, you may have anincreased chance of occurring a skin disease while taking Psorid 50mgcapsules.
While on treatment with Psorid   medication may cause hypertension and renal disease.
When administrating Psorid 50mgmay cause liver repair and liver failure, specifically if you take high doses. It may even be fatal.

DRUG INTERACTION

  • Adalimumab concomitant use with Psorid both increase immunosuppressive effects and cause risk of infection. Avoid the usage of drug
  • Psorid Interaction with carbamazepine will reduce the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid the usage of drug or Use Alternate Drug.
  • Acyclovir concomitant use with Psorid both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
  • Psorid increases levels of digoxin by lowering renal clearance. Avoid the usage of drug or Use Alternate Drug.
  • Azathioprine concomitant use with Psorid both increase immunosuppressive effects and cause risk of infection

CONTRAINDICATION

Psorid   is a contraindicated :

Hypersensitivity

Breastfeeding

Uses of Rheumatoid Arthritis (RA)/Psoriasis: Abnormal renal function, uncontrolled hypertension, malignancies Concomitant use of PUVA, UVB radiation, coal tar, methotrexate, other immunosuppressants will cause psoriasis

PREGNANCY

Psorid   Pregnancy category is C

The drug has no enough research done in humans to be certain how the drug might affect the foetus.

LACTATION

Psorid   excreted through breast milk and may leads to severe negative effects. Avoid using Psorid during breastfeeding.

STORAGE AND HANDLING

The drug stored at 20°C-25°C.

Avoid the drug placing in moist or damp areas.

Protect away from light and high temperature.

MISSED DOSE

The patients forget to take a dose then have it soon the missed dose or leave the missed dose and follow regular schedule. Avoid taking extra dose

Consult the doctor for more details

 

 

Feature
Brand name
Psorid
Active substance
Cyclosporine 100mg
Manufacturer
Biocon Ltd
Packaging
50 Capsules
Product form
Capsules
Strength
100mg
Psorid 100mg отзывы
Add a comment
0

We use cookies to make the site better for you! Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educati
Lorem Ipsum adalah text contoh digunakan didalam industri pencetakan dan typesetting. Lorem Ipsum telah menjadi text contoh semenjak tahun ke 1500an, apabila pencetak yang kurang terkenal mengambil sebuah galeri cetak dan merobakanya menjadi satu buku spe