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Xovoltib 20mg

Xovoltib 20mg (Afatinib)

Xovoltib 20mg is used for the first-line treatment for patients with metastatic non-small cell lung cancer(NSCLC)

Feature
Brand name:
Xovoltib
Active substance:
Afatinib 20mg
Manufacturer:
Boehringer Ingelheim
Packaging:
28 Tablets
Product form:
Tablet
Categories
In stock
Active substance: Afatinib
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Description

DESCRIPTION

This is a Phase 2 trial examine the performance of a targeted cancer drug known as Xovoltib 20mg.
Xovoltib 20mg prohibits the EGFR protein, which is accepting to be included in driving the growth of chordoma tumors.
This study is plan specifically for chordoma patients 18 years or older with recurrent or metastatic tumors.
Xovoltib 20mg which is used as prescription drugs under the guidance of oncologist physician.

INDICATION

Xovoltib 20mg is used for the first-line treatment for patients with metastatic non-small cell lung cancer(NSCLC)

MECHANISM OF ACTION

Afatinib mechanism by preventing the activity of a group of proteins knowns as epidermal growth factor receptors (EGFR). Epidermal growth factor receptor is a protein which is included in the growth and spread of cancer cells; Afatinib works by inhibiting the action of this protein.
Afatinib should not be taken by people who having EGFR-negative tumors.

PHARMACOKINETIC

  • Time to peak plasma time is 2-5 hr and bioavailability are 92 %
    • Human plasma protein bound is 95%
    • The major circulating metabolites are covalent adducts to proteins.
    • The drug excretion through feces is 85% and urine 4% • Half-life is 37 hr.

DOSAGE MANAGEMENT

For adult: 40mg taken once per day is the prescribed dose for adult patients with metastatic non-small cell lung cancer Age of 0-17 years prescribed dose is not being studied in children.
Avoid using of Xovoltib drug under 18 years of age
The prescribed dose for renal impairment is given 30mg taken once per day
Administration :
Administer the drug Xovoltib on an empty stomach.
Take the drug Xovoltib 1 hour before or 2 hours after a meal
Avoid cutting or crushing the tablet
Overdosage:Overdose is reported in patients whom ingested 360mg of Xovoltib which causes in nausea, vomiting, asthenia, abdominal pain and hence provided supportive measurement for recovery.

PRECAUTION

Serious dehydration can occur with the use of Xovoltib 20mg. This may be leads to serious or persistent diarrhea, vomiting, or reduced fluid intake. Dehydration can result in kidney failure, if it is severe enough. While on treatment with this medication, you may be encouraged to drink extra water.
During treatment with Xovoltib 20mg will result in hepatotoxicity; monitor with periodic liver testing; withhold or stoptreatment for serious or worsening liver tests
The drug may result in Interstitial lung disease (ILD)
when administrated to pregnant women, Xovoltib 20mg will have foetus harm (embryo-fetal toxicity)
Discontinue the drug,if patients confirm with suspected keratitis or ulcerative keratitis
With Xovoltib 20mg have increased sunburn/phototoxicity; may aggravate rash or acne; patients use with caution to limit sun exposure and where sunscreen and protective clothing.
sometimes, Xovoltib 20mg has been bind to corneal perforation, a serious injury to the part of the eye which focuses light into the eye. If you have any persistent eye pain or changes in vision, inform your doctor immediately.

SIDE EFFECTS

Common side effects caused :
• Mild diarrhae for 1 day or less
• Decreased appetite
• Nausea and vomiting
• Mouth ulcer
• Acne, itching, dry skin
• Red colour, tenderness, swelling or other signs of infection around your fingernails or toenails
Serious side effects :
• Eye problems – blurred vision, watery eyes, increased sensitivity to light
• Liver problem – stomach pain, feeling tried, dark urine
• Heart problem
• Urine colour changes to dark
• Bleeding or bruising
• Weakness
• Blurred vision
• Rapid heartbeat
• Breathing trouble
• Cough and fever
• Yellowing the skins

DRUG INTERACTION

Co administration of Xovoltib 20mg with P-gp inhibitors (cyclosporine A, ketoconazole verapamil) will have high exposure to Afatinib
When interaction of Xovoltib 20mg with P-gp inducers (carbamazepine, phenytoin, phenobarbital) will lowers the exposure to Afatinib

PREGNANCY

Pregnancy category: c
During treatment with Xovoltib 20mg Pregnancy should avoid because the drug Xovoltib 20mg is administrated to a pregnant woman will harm the foetus.

LACTATION

Xovoltib 20mg Excretion into human milk is unknown or will have adverse reaction in a child who is breastfed. Hence decision can take whether to stop breastfeeding or discontinuation of medicine.

STORAGE

  • Xovoltib 20mgStore at 25°C
    • Keep Xovoltib 20mg away from children
    • Protect away free from moisture and light.

MISSED DOSE

If patient missed to take the dose of Xovoltib 20mg, then the missed dose must be skipped and follow the regular dosing schedule. Do not administerdouble the dose

Consult with doctor and follow the suggestions.

Feature
Brand name
Xovoltib
Active substance
Afatinib 20mg
Manufacturer
Boehringer Ingelheim
Packaging
28 Tablets
Product form
Tablet
Strength
20mg
Xovoltib 20mg отзывы
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